Cargando…

What does heritability of Alzheimer’s disease represent?

INTRODUCTION: Both late-onset Alzheimer’s disease (AD) and ageing have a strong genetic component. In each case, many associated variants have been discovered, but how much missing heritability remains to be discovered is debated. Variability in the estimation of SNP-based heritability could explain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baker, Emily, Leonenko, Ganna, Schmidt, Karl Michael, Hill, Matthew, Myers, Amanda J., Shoai, Maryam, de Rojas, Itziar, Tesi, Niccoló, Holstege, Henne, van der Flier, Wiesje M., Pijnenburg, Yolande A. L., Ruiz, Agustin, Hardy, John, van der Lee, Sven, Escott-Price, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146480/ https://www.ncbi.nlm.nih.gov/pubmed/37115753 http://dx.doi.org/10.1371/journal.pone.0281440

Ejemplares similares

Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition
por: Leonenko, Ganna, et al.
Publicado: (2019)

Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s disease
por: Tesi, Niccolò, et al.
Publicado: (2020)

Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum
por: Tesi, Niccolo’, et al.
Publicado: (2020)

The Effect of Alzheimer’s Disease-Associated Genetic Variants on Longevity
por: Tesi, Niccolò, et al.
Publicado: (2021)

snpXplorer: a web application to explore human SNP-associations and annotate SNP-sets
por: Tesi, Niccolo, et al.
Publicado: (2021)

Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins
por: Karlsson, Ida K., et al.
Publicado: (2022)

Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease
por: Tesi, Niccolò, et al.
Publicado: (2018)

A novel CCM2 variant in a family with non‐progressive cognitive complaints and cerebral microbleeds
por: Cohn‐Hokke, Petra E., et al.
Publicado: (2016)

Polygenic risk and hazard scores for Alzheimer's disease prediction
por: Leonenko, Ganna, et al.
Publicado: (2019)

Genetics Contributes to Concomitant Pathology and Clinical Presentation in Dementia with Lewy Bodies
por: van der Lee, Sven J., et al.
Publicado: (2021)

Polygenic Risk Score Analysis of Alzheimer’s Disease in Cases without APOE4 or APOE2 Alleles
por: Escott-Price, V., et al.
Publicado: (2018)

Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory
por: de Haan, Willem, et al.
Publicado: (2009)

Comparison of long-term effects of metformin on longevity between people with type 2 diabetes and matched non-diabetic controls
por: Stevenson-Hoare, Joshua, et al.
Publicado: (2023)

Discriminative and prognostic potential of cerebrospinal fluid phosphoTau/tau ratio and neurofilaments for frontotemporal dementia subtypes
por: Pijnenburg, Yolande A.L., et al.
Publicado: (2015)

Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study
por: Beker, Nina, et al.
Publicado: (2020)

Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score
por: Ebenau, Jarith L., et al.
Publicado: (2021)

Rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer’s Disease in a Family with Several Generations of APOE-ɛ4 Homozygosity
por: Louwersheimer, Eva, et al.
Publicado: (2017)

Short Digital Spatial Memory Test Detects Impairment in Alzheimer’s Disease and Mild Cognitive Impairment
por: Poos, Jackie M., et al.
Publicado: (2021)

Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis
por: Bracher-Smith, Matthew, et al.
Publicado: (2022)

Amyloid‐β, cortical thickness, and subsequent cognitive decline in cognitively normal oldest‐old
por: Pelkmans, Wiesje, et al.
Publicado: (2021)

Age-dependent effect of APOE and polygenic component on Alzheimer's disease
por: Bellou, Eftychia, et al.
Publicado: (2020)

Defining functional variants associated with Alzheimer’s disease in the induced immune response
por: Harwood, Janet C, et al.
Publicado: (2021)

Visual assessment of posterior atrophy development of a MRI rating scale
por: Koedam, Esther L. G. E., et al.
Publicado: (2011)

Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
por: Leonenko, Ganna, et al.
Publicado: (2021)

Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families
por: Mol, Merel O., et al.
Publicado: (2022)

Survival in memory clinic cohort is short, even in young-onset dementia
por: Rhodius-Meester, Hanneke Frederica Maria, et al.
Publicado: (2019)

Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals
por: Heeman, Fiona, et al.
Publicado: (2022)

Clinical outcomes up to 9 years after [(18)F]flutemetamol amyloid-PET in a symptomatic memory clinic population
por: Collij, Lyduine E., et al.
Publicado: (2023)

Amsterdam Dementia Cohort: Performing Research to Optimize Care
por: van der Flier, Wiesje M., et al.
Publicado: (2018)

A clinical-radiological framework of the right temporal variant of frontotemporal dementia
por: Ulugut Erkoyun, Hulya, et al.
Publicado: (2020)

Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological repeat expansions
por: Reus, Lianne M., et al.
Publicado: (2021)

Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer’s disease through polygenic risk and RNA sequencing
por: Crawford, Karen, et al.
Publicado: (2022)

YKL-40 changes are not detected in post-mortem brain of patients with Alzheimer’s disease and frontotemporal lobar degeneration
por: Hok-A-Hin, Yanaika S., et al.
Publicado: (2022)

Joint assessment of white matter integrity, cortical and subcortical atrophy to distinguish AD from behavioral variant FTD: A two-center study
por: Möller, Christiane, et al.
Publicado: (2015)

Identifying best practices for disclosure of amyloid imaging results: A randomized controlled trial
por: Fruijtier, Agnetha D., et al.
Publicado: (2022)

Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia
por: Thijssen, Elisabeth H., et al.
Publicado: (2022)

Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease
por: Hafkemeijer, Anne, et al.
Publicado: (2015)

Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum
por: Meeter, Lieke H.H., et al.
Publicado: (2018)

Self-reported oral health in the Dutch 100-plus Study of cognitively healthy centenarians: an observational cohort study
por: Beker, Nina, et al.
Publicado: (2019)

The Right Temporal Variant of Frontotemporal Dementia Is Not Genetically Sporadic: A Case Series
por: Ulugut Erkoyun, Hulya, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_li47eh6ohfq0euu58t5ae8b240