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IL-17 cytokines preferentially act on naïve CD4(+) T cells with the IL-17AF heterodimer inducing the greatest functional changes

CD4(+) T-helper 17 (Th17) T cells are a key population in protective immunity during infection and in self-tolerance/autoimmunity. Through the secretion of IL-17, Th17 cells act in promotion of inflammation and are thus a major potential therapeutic target in autoimmune disorders. Recent reports hav...

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Detalles Bibliográficos
Autores principales: Crawford, Michael P., Borcherding, Nicholas, Karandikar, Nitin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10146571/
https://www.ncbi.nlm.nih.gov/pubmed/37115755
http://dx.doi.org/10.1371/journal.pone.0285166