Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2

Mutations in the ubiquitin (Ub) chaperone Ubiquilin 2 (UBQLN2) cause X-linked forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) through unknown mechanisms. Here, we show that aggregation-prone, ALS-associated mutants of UBQLN2 (UBQLN2(ALS)) trigger heat stress-dependent...

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Detalles Bibliográficos
Autores principales: Kim, Sang Hwa, Nichols, Kye D, Anderson, Eric N, Liu, Yining, Ramesh, Nandini, Jia, Weiyan, Kuerbis, Connor J, Scalf, Mark, Smith, Lloyd M, Pandey, Udai Bhan, Tibbetts, Randal S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147378/
https://www.ncbi.nlm.nih.gov/pubmed/37039476
http://dx.doi.org/10.7554/eLife.84382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147378/
https://www.ncbi.nlm.nih.gov/pubmed/37039476
http://dx.doi.org/10.7554/eLife.84382

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