Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells

Embryonic stem cells (ESCs) are superior to differentiated cells to maintain genome stability, but the underlying mechanisms remain largely elusive. R-loops are constantly formed during transcription and are inducers of DNA damage if not resolved. Here we report that mouse ESCs (mESCs) can efficient...

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Detalles Bibliográficos
Autores principales: Gong, Daohua, Wang, Lin, Zhou, Hu, Gao, Jing, Zhang, Weidao, Zheng, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147553/
https://www.ncbi.nlm.nih.gov/pubmed/36931280
http://dx.doi.org/10.1016/j.stemcr.2023.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147553/
https://www.ncbi.nlm.nih.gov/pubmed/36931280
http://dx.doi.org/10.1016/j.stemcr.2023.02.003

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