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Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells
Iron, supplemented as iron-loaded transferrin (holotransferrin), is an essential nutrient in mammalian cell cultures, particularly for erythroid cultures. The high cost of human transferrin represents a challenge for large scale production of red blood cells (RBCs) and for cell therapies in general....
Autores principales: | Gallego-Murillo, Joan Sebastián, Yağcı, Nurcan, Pinho, Eduardo Machado, Wahl, Sebastian Aljoscha, van den Akker, Emile, von Lindern, Marieke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147612/ https://www.ncbi.nlm.nih.gov/pubmed/37117329 http://dx.doi.org/10.1038/s41598-023-32706-1 |
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