Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer

BACKGROUND: One-third of cancers activate endogenous synthesis of serine/glycine, and can become addicted to this pathway to sustain proliferation and survival. Mechanisms driving this metabolic rewiring remain largely unknown. METHODS: NKX2–1 overexpressing and NKX2–1 knockdown/knockout T-cell leuk...

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Detalles Bibliográficos
Autores principales: Heylen, Elien, Verstraete, Paulien, Van Aerschot, Linde, Geeraerts, Shauni L., Venken, Tom, Timcheva, Kalina, Nittner, David, Verbeeck, Jelle, Royaert, Jonathan, Gijbels, Marion, Uyttebroeck, Anne, Segers, Heidi, Lambrechts, Diether, Cools, Jan, De Keersmaecker, Kim, Kampen, Kim R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147615/
https://www.ncbi.nlm.nih.gov/pubmed/36932191
http://dx.doi.org/10.1038/s41416-023-02216-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147615/
https://www.ncbi.nlm.nih.gov/pubmed/36932191
http://dx.doi.org/10.1038/s41416-023-02216-y

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