Cargando…
Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics
BACKGROUND: Autophagy plays an important role in tumour cell growth and survival and also promotes resistance to chemotherapy. Hence, autophagy has been targeted for cancer therapy. We previously reported that macrolide antibiotics including azithromycin (AZM) inhibit autophagy in various types of c...
Autores principales: | Takano, Naoharu, Hiramoto, Masaki, Yamada, Yumiko, Kokuba, Hiroko, Tokuhisa, Mayumi, Hino, Hirotsugu, Miyazawa, Keisuke |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147625/ https://www.ncbi.nlm.nih.gov/pubmed/36871041 http://dx.doi.org/10.1038/s41416-023-02210-4 |
Ejemplares similares
-
Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021) -
Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin
por: Tanaka, Hideki, et al.
Publicado: (2020) -
Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
por: Toriyama, Kazutoshi, et al.
Publicado: (2021) -
Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes
por: Hino, Hirotsugu, et al.
Publicado: (2020) -
Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization-associated cell death
por: Takeda, Atsuo, et al.
Publicado: (2020)