Cargando…

Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics

BACKGROUND: Autophagy plays an important role in tumour cell growth and survival and also promotes resistance to chemotherapy. Hence, autophagy has been targeted for cancer therapy. We previously reported that macrolide antibiotics including azithromycin (AZM) inhibit autophagy in various types of c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takano, Naoharu, Hiramoto, Masaki, Yamada, Yumiko, Kokuba, Hiroko, Tokuhisa, Mayumi, Hino, Hirotsugu, Miyazawa, Keisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147625/ https://www.ncbi.nlm.nih.gov/pubmed/36871041 http://dx.doi.org/10.1038/s41416-023-02210-4

Ejemplares similares

Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021)

Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin
por: Tanaka, Hideki, et al.
Publicado: (2020)

Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
por: Toriyama, Kazutoshi, et al.
Publicado: (2021)

Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes
por: Hino, Hirotsugu, et al.
Publicado: (2020)

Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization-associated cell death
por: Takeda, Atsuo, et al.
Publicado: (2020)

Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression
por: Moriya, Shota, et al.
Publicado: (2023)

BRCA1 degradation in response to mitochondrial damage in breast cancer cells
por: Miyahara, Kana, et al.
Publicado: (2021)

Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis
por: Saito, Yu, et al.
Publicado: (2018)

Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells
por: Miyake, Keitaro, et al.
Publicado: (2022)

Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells
por: MORIYA, SHOTA, et al.
Publicado: (2014)

Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells
por: Hattori, Kazuhiro, et al.
Publicado: (2021)

p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs
por: Yamashita, Gai, et al.
Publicado: (2022)

Lysosome-targeted drug combination induces multiple organelle dysfunctions and non-canonical death in pancreatic cancer cells
por: Suzuki, Sumire, et al.
Publicado: (2022)

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines
por: MUKAI, SHUNTARO, et al.
Publicado: (2015)

Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines
por: Miyahara, Kana, et al.
Publicado: (2016)

Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines
por: Hirasawa, Kazuhiro, et al.
Publicado: (2016)

Effects of cytoskeletal perturbant drugs on ecto 5'-nucleotidase, a concanavalin A receptor
Publicado: (1979)

Perturbation of Wound Healing, Cytoskeletal Organization and Cellular Protein Networks during Hazara Virus Infection
por: Molinas, Andrea, et al.
Publicado: (2017)

The Contribution of Lysosomotropism to Autophagy Perturbation
por: Ashoor, Roshan, et al.
Publicado: (2013)

Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis
por: Yamane, Mototeru, et al.
Publicado: (2017)

Cytoskeletal Control of Planar Polarity in Root Hair Development
por: Takatsuka, Hirotomo, et al.
Publicado: (2020)

Inhibitors of cytoskeletal dynamics in malignant mesothelioma
por: Reis, Katarina, et al.
Publicado: (2020)

Perturbing Dynamin Reveals Potent Effects on the Drosophila Circadian Clock
por: Kilman, Valerie L., et al.
Publicado: (2009)

Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy
por: Ueda, Hiroko, et al.
Publicado: (2023)

Cytoskeletal vimentin regulates cell size and autophagy through mTORC1 signaling
por: Mohanasundaram, Ponnuswamy, et al.
Publicado: (2022)

A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a, potentially affecting CDKN1C expression
por: Hiramoto, Masaki, et al.
Publicado: (2018)

Kinetics and protective role of autophagy in a mouse cecal ligation and puncture-induced sepsis
por: Takahashi, Waka, et al.
Publicado: (2013)

Azithromycin (Zithromax(®))
por: McCarty, James M.
Publicado: (1996)

Azithromycin for Malaria?
por: Rosenthal, Philip J.
Publicado: (2016)

Cytoskeletal Proteins of Actinobacteria
por: Letek, Michal, et al.
Publicado: (2012)

Cytoskeletal Remodeling in Cancer
por: Aseervatham, Jaya
Publicado: (2020)

Cytoskeletal Tensegrity in Microgravity
por: Gardiner, John
Publicado: (2021)

Poor oral health and mortality in geriatric patients admitted to an acute hospital: an observational study
por: Maeda, Keisuke, et al.
Publicado: (2020)

EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma
por: Katschnig, A M, et al.
Publicado: (2017)

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors
por: Lazarus, Michael B., et al.
Publicado: (2014)

Novel Potent Autophagy Inhibitor Ka-003 Inhibits Dengue Virus Replication
por: Limthongkul, Jitra, et al.
Publicado: (2023)

Azithromycin in viral infections
por: Oliver, Madeleine E., et al.
Publicado: (2020)

Azithromycin in acute bronchiolitis
por: Solé, Dirceu, et al.
Publicado: (2020)

Azithromycin-Induced Bradycardia
por: Abdelazeem, Basel, et al.
Publicado: (2021)

Rhabdomyolysis triggered by azithromycin
por: Finsterer, Josef, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3vfejlfedkgmpdtrjd0g1dbr9e