The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner

Recombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to the observed discordance in vector-mediated transduction bet...

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Detalles Bibliográficos
Autores principales: Gonzalez-Sandoval, Adriana, Pekrun, Katja, Tsuji, Shinnosuke, Zhang, Feijie, Hung, King L., Chang, Howard Y., Kay, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147666/
https://www.ncbi.nlm.nih.gov/pubmed/37117181
http://dx.doi.org/10.1038/s41467-023-38106-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147666/
https://www.ncbi.nlm.nih.gov/pubmed/37117181
http://dx.doi.org/10.1038/s41467-023-38106-3

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