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The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner
Recombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to the observed discordance in vector-mediated transduction bet...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147666/ https://www.ncbi.nlm.nih.gov/pubmed/37117181 http://dx.doi.org/10.1038/s41467-023-38106-3 |