Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues

Ischemic heart failure is due to irreversible loss of cardiomyocytes. Preclinical studies showed that human pluripotent stem cell (hPSC)-derived cardiomyocytes could remuscularize infarcted hearts and improve cardiac function. However, these cardiomyocytes remained immature. Incorporating hPSC-deriv...

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Detalles Bibliográficos
Autores principales: Ong, Lay Ping, Bargehr, Johannes, Knight-Schrijver, Vincent R., Lee, Jonathan, Colzani, Maria, Bayraktar, Semih, Bernard, William G., Marchiano, Silvia, Bertero, Alessandro, Murry, Charles E., Gambardella, Laure, Sinha, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147941/
https://www.ncbi.nlm.nih.gov/pubmed/37001515
http://dx.doi.org/10.1016/j.stemcr.2023.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10147941/
https://www.ncbi.nlm.nih.gov/pubmed/37001515
http://dx.doi.org/10.1016/j.stemcr.2023.03.002

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