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APP and Bace1: Differential effect of cholesterol enrichment on processing and plasma membrane mobility
High cholesterol levels are a risk factor for the development of Alzheimer’s disease. Experiments investigating the influence of cholesterol on the proteolytic processing of the amyloid precursor protein (APP) by the β-secretase Bace1 and on their proximity in cells have led to conflicting results....
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148118/ https://www.ncbi.nlm.nih.gov/pubmed/37128606 http://dx.doi.org/10.1016/j.isci.2023.106611 |