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ATG9 vesicles comprise the seed membrane of mammalian autophagosomes

As the autophagosome forms, its membrane surface area expands rapidly, while its volume is kept low. Protein-mediated transfer of lipids from another organelle to the autophagosome likely drives this expansion, but as these lipids are only introduced into the cytoplasmic-facing leaflet of the organe...

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Detalles Bibliográficos
Autores principales: Olivas, Taryn J., Wu, Yumei, Yu, Shenliang, Luan, Lin, Choi, Peter, Guinn, Emily D., Nag, Shanta, De Camilli, Pietro V., Gupta, Kallol, Melia, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148236/
https://www.ncbi.nlm.nih.gov/pubmed/37115958
http://dx.doi.org/10.1083/jcb.202208088