Cargando…

Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses

BACKGROUND: Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is critical for cytosolic DNA-sensing and the subsequent immune responses. The inappropriate activation of this pathway leads to DNA-induced autoimmune response. Understanding the precise regulation of cGAS-STI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Yu, Wang, Miao, Li, Xiao-Wei, Mao, Jie, Zhu, Ying-Jie, Wang, Na, Yin, Le-Hua, Guo, Zeng-Lin, Cai, Hong, Li, Tao, Liang, Ting-Ting, Cui, Jiuwei, Zhou, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148517/ https://www.ncbi.nlm.nih.gov/pubmed/37120570 http://dx.doi.org/10.1186/s13578-023-01025-3

Ejemplares similares

Meloxicam Alleviates Sepsis-Induced Kidney Injury by Suppression of Inflammation and Apoptosis via Upregulating GPNMB
por: Zhao, Shilei, et al.
Publicado: (2022)

Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases
por: Navarro-Ruíz, Eva, et al.
Publicado: (2022)

Evaluation on monoamine neurotransmitters changes in depression rats given with sertraline, meloxicam or/and caffeic acid
por: Huang, Dan, et al.
Publicado: (2018)

Metformin promotes cGAS/STING signaling pathway activation by blocking AKT phosphorylation in gastric cancer
por: Shen, Qian, et al.
Publicado: (2023)

Meloxicam-Induced Pancreatitis
por: Landa, Eric, et al.
Publicado: (2021)

Meloxicam hydrochloride
por: Flores Manuel, Fermin, et al.
Publicado: (2023)

Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites
por: Mu, Lingli, et al.
Publicado: (2016)

Astragaloside IV Regulates cGAS-STING Signaling Pathway to Alleviate Immunosuppression Caused by PRRSV Infection
por: Song, Ke, et al.
Publicado: (2023)

Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation
por: Yu, Jian-shuai, et al.
Publicado: (2021)

STING activation in cancer immunotherapy
por: Su, Ting, et al.
Publicado: (2019)

The effect of topical application of meloxicam on inflamed dental pulp
por: Li, Jing-Yi, et al.
Publicado: (2021)

Retracted: Meloxicam Alleviates Sepsis-Induced Kidney Injury by Suppression of Inflammation and Apoptosis via Upregulating GPNMB
por: and Biomechanics, Applied Bionics
Publicado: (2023)

P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway
por: Yu, Yeping, et al.
Publicado: (2023)

Stability Indicating HPTLC Determination of Meloxicam
por: Desai, Namita, et al.
Publicado: (2008)

Bioavailability and pharmacokinetics of oral meloxicam in llamas
por: Kreuder, Amanda J, et al.
Publicado: (2012)

Benzoylaconitine Alleviates Progression of Psoriasis via Suppressing STAT3 Phosphorylation in Keratinocytes
por: Li, Yuanbo, et al.
Publicado: (2023)

p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation
por: Chen, Yunfei, et al.
Publicado: (2017)

Dampened STING-Dependent Interferon Activation in Bats
por: Xie, Jiazheng, et al.
Publicado: (2018)

cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE
por: Motwani, Mona, et al.
Publicado: (2021)

Impact of STING Inflammatory Signaling during Intracellular Bacterial Infections
por: Guimarães, Erika S., et al.
Publicado: (2021)

Preparation and In Vitro and In Vivo Evaluation of Rectal In Situ Gel of Meloxicam Hydroxypropyl-β-cyclodextrin Inclusion Complex
por: Lei, Xiaomeng, et al.
Publicado: (2023)

ROP16 of Toxoplasma gondii Inhibits Innate Immunity by Triggering cGAS-STING Pathway Inactivity through the Polyubiquitination of STING
por: Jin, Qi-Wang, et al.
Publicado: (2023)

Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, in vitro and in vivo evaluation
por: Yu, Qin, et al.
Publicado: (2018)

The protection of meloxicam against chronic aluminium overload-induced liver injury in rats
por: Yang, Yang, et al.
Publicado: (2017)

Inhibitors of IFN gene stimulators (STING) improve intestinal ischemia–reperfusion-induced acute lung injury by activating AMPK signaling
por: Yang, Mei, et al.
Publicado: (2022)

STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage
por: Wang, Chenyao, et al.
Publicado: (2023)

The Evaluation of Meloxicam Nanocrystals by Oral Administration with Different Particle Sizes
por: Yu, Yao, et al.
Publicado: (2022)

Optimization of the sonication process for meloxicam nanocrystals preparation
por: IURIAN, SONIA, et al.
Publicado: (2015)

Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
por: Huang, Shan, et al.
Publicado: (2022)

Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents
por: Gaston, Julie, et al.
Publicado: (2016)

A novel albumin wrapped nanosuspension of meloxicam to improve inflammation-targeting effects
por: Li, Qi, et al.
Publicado: (2018)

Updated roles of cGAS-STING signaling in autoimmune diseases
por: Liu, Ya, et al.
Publicado: (2023)

A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation
por: Takahashi, Kanoko, et al.
Publicado: (2021)

Synergistic Antinociceptive Effects of Indomethacin–Pregabalin and Meloxicam–Pregabalin in Paclitaxel-Induced Neuropathic Pain
por: Ma, Yurong, et al.
Publicado: (2022)

TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy
por: Li, Yan, et al.
Publicado: (2023)

Interruption of post-Golgi STING trafficking activates tonic interferon signaling
por: Tu, Xintao, et al.
Publicado: (2022)

Controlled intracellular trafficking alleviates an expression bottleneck in S. cerevisiae ester biosynthesis
por: Zhu, Jie, et al.
Publicado: (2018)

Meloxicam Inhibited the Proliferation of LPS-Stimulated Bovine Endometrial Epithelial Cells Through Wnt/β-Catenin and PI3K/AKT Pathways
por: Cui, Luying, et al.
Publicado: (2021)

Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
por: Li, Qiumei, et al.
Publicado: (2021)

Therapeutic role of meloxicam targeting secretory clusterin-mediated invasion in hepatocellular carcinoma cells
por: Zhong, Jingtao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ha64tg1g32jn1g03atkp6u4uj3