Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

HIV-1 reverse transcriptase is one of the most attractive targets for the treatment of AIDS. However, the rapid emergence of drug-resistant strains and unsatisfactory drug-like properties seriously limit the clinical application of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Here...

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Detalles Bibliográficos
Autores principales: Jiang, Xiangyi, Huang, Boshi, Rumrill, Shawn, Pople, David, Zalloum, Waleed A., Kang, Dongwei, Zhao, Fabao, Ji, Xiangkai, Gao, Zhen, Hu, Lide, Wang, Zhao, Xie, Minghui, De Clercq, Erik, Ruiz, Francesc X., Arnold, Eddy, Pannecouque, Christophe, Liu, Xinyong, Zhan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148624/
https://www.ncbi.nlm.nih.gov/pubmed/37120482
http://dx.doi.org/10.1038/s42004-023-00888-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148624/
https://www.ncbi.nlm.nih.gov/pubmed/37120482
http://dx.doi.org/10.1038/s42004-023-00888-4

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