A structural model of the iRhom–ADAM17 sheddase complex reveals functional insights into its trafficking and activity

Several membrane-anchored signal mediators such as cytokines (e.g. TNFα) and growth factors are proteolytically shed from the cell surface by the metalloproteinase ADAM17, which, thus, has an essential role in inflammatory and developmental processes. The membrane proteins iRhom1 and iRhom2 are inst...

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Detalles Bibliográficos
Autores principales: Kahveci-Türköz, Selcan, Bläsius, Katharina, Wozniak, Justyna, Rinkens, Cindy, Seifert, Anke, Kasparek, Petr, Ohm, Henrike, Oltzen, Shixin, Nieszporek, Martin, Schwarz, Nicole, Babendreyer, Aaron, Preisinger, Christian, Sedlacek, Radislav, Ludwig, Andreas, Düsterhöft, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148629/
https://www.ncbi.nlm.nih.gov/pubmed/37119365
http://dx.doi.org/10.1007/s00018-023-04783-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148629/
https://www.ncbi.nlm.nih.gov/pubmed/37119365
http://dx.doi.org/10.1007/s00018-023-04783-y

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