Synthesis of Amino Acids Bearing Halodifluoromethyl Moieties and Their Application to p53-Derived Peptides Binding to Mdm2/Mdm4

INTRODUCTION: Therapeutic peptides are a significant class of drugs in the treatment of a wide range of diseases. To enhance their properties, such as stability or binding affinity, they are usually chemically modified. This includes, among other techniques, cyclization of the peptide chain by bridg...

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Detalles Bibliográficos
Autores principales: Vaas, Sebastian, Zimmermann, Markus O, Klett, Theresa, Boeckler, Frank M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148652/
https://www.ncbi.nlm.nih.gov/pubmed/37128274
http://dx.doi.org/10.2147/DDDT.S406703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148652/
https://www.ncbi.nlm.nih.gov/pubmed/37128274
http://dx.doi.org/10.2147/DDDT.S406703

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