Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration

PURPOSE: The unfolded protein response (UPR) is triggered when the protein folding capacity of the endoplasmic reticulum (ER) is overwhelmed and misfolded proteins accumulate in the ER, a condition referred to as ER stress. IRE1α is an ER-resident protein that plays major roles in orchestrating the...

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Detalles Bibliográficos
Autores principales: Massoudi, Dawiyat, Gorman, Seán, Kuo, Yien-Ming, Iwawaki, Takao, Oakes, Scott A., Papa, Feroz R., Gould, Douglas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148664/
https://www.ncbi.nlm.nih.gov/pubmed/37097227
http://dx.doi.org/10.1167/iovs.64.4.30

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148664/
https://www.ncbi.nlm.nih.gov/pubmed/37097227
http://dx.doi.org/10.1167/iovs.64.4.30

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