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Oridonin inhibits SARS-CoV-2 replication by targeting viral proteinase and polymerase

COVID-19 has become a global public health crisis since its outbreak in China in December 2019. Currently there are few clinically effective drugs to combat SARS-CoV-2 infection. The main protein (M(pro)), papain-like protease (PL(pro)) and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 are invol...

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Detalles Bibliográficos
Autores principales: Zhang, Zherui, Zhang, Hongqing, Zhang, Yanan, Zhang, Qiuyan, Liu, Qiaojie, Hu, Yanyan, Chen, Xiaoling, Wang, Jing, Shi, Yujia, Deng, Chenglin, Gong, Peng, Zhang, Bo, Li, Xiaodan, Zhu, Bing, Ye, Hanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148713/
https://www.ncbi.nlm.nih.gov/pubmed/37127212
http://dx.doi.org/10.1016/j.virs.2023.04.008