Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling

Adhesion G Protein Coupled Receptors (aGPCRs) have evolved an activation mechanism to translate extracellular force into liberation of a tethered agonist (TA) to effect cell signalling. We report here that ADGRF1 can signal through all major G protein classes and identify the structural basis for a...

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Detalles Bibliográficos
Autores principales: Jones, Daniel T. D., Dates, Andrew N., Rawson, Shaun D., Burruss, Maggie M., Lipper, Colin H., Blacklow, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148833/
https://www.ncbi.nlm.nih.gov/pubmed/37120430
http://dx.doi.org/10.1038/s41467-023-38083-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148833/
https://www.ncbi.nlm.nih.gov/pubmed/37120430
http://dx.doi.org/10.1038/s41467-023-38083-7

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