Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5′-termini of RNA and polymerase function

The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and replication of the viral RNA genome in a temporally ordered manner. Although the structure of polymerase is well understood, our knowledge of its regulation by p...

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Detalles Bibliográficos
Autores principales: Liu, Lu, Madhugiri, Ramakanth, Saul, Vera Vivian, Bacher, Susanne, Kracht, Michael, Pleschka, Stephan, Schmitz, M. Lienhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148841/
https://www.ncbi.nlm.nih.gov/pubmed/37120635
http://dx.doi.org/10.1038/s41598-023-34285-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148841/
https://www.ncbi.nlm.nih.gov/pubmed/37120635
http://dx.doi.org/10.1038/s41598-023-34285-7

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