Synthetic lethality prediction in DNA damage repair, chromatin remodeling and the cell cycle using multi-omics data from cell lines and patients.

Discovering synthetic lethal (SL) gene partners of cancer genes is an important step in developing cancer therapies. However, identification of SL interactions is challenging, due to a large number of possible gene pairs, inherent noise and confounding factors in the observed signal. To discover rob...

Descripción completa

Detalles Bibliográficos
Autores principales: Markowska, Magda, Budzinska, Magdalena A., Coenen-Stass, Anna, Kang, Senbai, Kizling, Ewa, Kolmus, Krzysztof, Koras, Krzysztof, Staub, Eike, Szczurek, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148866/
https://www.ncbi.nlm.nih.gov/pubmed/37120674
http://dx.doi.org/10.1038/s41598-023-34161-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148866/
https://www.ncbi.nlm.nih.gov/pubmed/37120674
http://dx.doi.org/10.1038/s41598-023-34161-4

Ejemplares similares