Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks

Expanded CAG/CTG repeats are sites of DNA damage, leading to repeat length changes. Homologous recombination (HR) is one cause of repeat instability and we hypothesized that gap filling was a driver of repeat instability during HR. To test this, we developed an assay such that resection and ssDNA ga...

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Detalles Bibliográficos
Autores principales: Polleys, Erica J., Del Priore, Isabella, Haber, James E., Freudenreich, Catherine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148874/
https://www.ncbi.nlm.nih.gov/pubmed/37120647
http://dx.doi.org/10.1038/s41467-023-37901-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148874/
https://www.ncbi.nlm.nih.gov/pubmed/37120647
http://dx.doi.org/10.1038/s41467-023-37901-2

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