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Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks
Expanded CAG/CTG repeats are sites of DNA damage, leading to repeat length changes. Homologous recombination (HR) is one cause of repeat instability and we hypothesized that gap filling was a driver of repeat instability during HR. To test this, we developed an assay such that resection and ssDNA ga...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148874/ https://www.ncbi.nlm.nih.gov/pubmed/37120647 http://dx.doi.org/10.1038/s41467-023-37901-2 |