Determination of significant immunological timescales from mRNA-LNP-based vaccines in humans

A compartment model for an in-host liquid nanoparticle delivered mRNA vaccine is presented. Through non-dimensionalisation, five timescales are identified that dictate the lifetime of the vaccine in-host: decay of interferon gamma, antibody priming, autocatalytic growth, antibody peak and decay, and...

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Detalles Bibliográficos
Autores principales: Moyles, Iain R., Korosec, Chapin S., Heffernan, Jane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149047/
https://www.ncbi.nlm.nih.gov/pubmed/37121986
http://dx.doi.org/10.1007/s00285-023-01919-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149047/
https://www.ncbi.nlm.nih.gov/pubmed/37121986
http://dx.doi.org/10.1007/s00285-023-01919-3

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