Antagonistic antimalarial properties of a methoxyamino chalcone derivative and 3-hydroxypyridinones in combination with dihydroartemisinin against Plasmodium falciparum

BACKGROUND: The spread of artemisinin (ART)-resistant Plasmodium falciparum threatens the control of malaria. Mutations in the propeller domains of P. falciparum Kelch13 (k13) are strongly associated with ART resistance. Ferredoxin (Fd), a component of the ferredoxin/NADP(+) reductase (Fd/FNR) redox...

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Detalles Bibliográficos
Autores principales: Kampoun, Tanyaluck, Koonyosying, Pimpisid, Ruangsuriya, Jetsada, Prommana, Parichat, Shaw, Philip J., Kamchonwongpaisan, Sumalee, Suwito, Hery, Puspaningsih, Ni Nyoman Tri, Uthaipibull, Chairat, Srichairatanakool, Somdet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149052/
https://www.ncbi.nlm.nih.gov/pubmed/37131988
http://dx.doi.org/10.7717/peerj.15187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149052/
https://www.ncbi.nlm.nih.gov/pubmed/37131988
http://dx.doi.org/10.7717/peerj.15187

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