A clinically relevant selective ERK-pathway inhibitor reverses core deficits in a mouse model of autism

BACKGROUND: Extracellular signal-regulated kinase (ERK/MAPK) pathway in the brain is hypothesized to be a critical convergent node in the development of autism spectrum disorder. We reasoned that selectively targeting this pathway could reverse core autism-like phenotype in animal models. METHODS: H...

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Detalles Bibliográficos
Autores principales: Murari, Kartikeya, Abushaibah, Abdulrahman, Rho, Jong M., Turner, Ray W., Cheng, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149189/
https://www.ncbi.nlm.nih.gov/pubmed/37088035
http://dx.doi.org/10.1016/j.ebiom.2023.104565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149189/
https://www.ncbi.nlm.nih.gov/pubmed/37088035
http://dx.doi.org/10.1016/j.ebiom.2023.104565

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