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A clinically relevant selective ERK-pathway inhibitor reverses core deficits in a mouse model of autism
BACKGROUND: Extracellular signal-regulated kinase (ERK/MAPK) pathway in the brain is hypothesized to be a critical convergent node in the development of autism spectrum disorder. We reasoned that selectively targeting this pathway could reverse core autism-like phenotype in animal models. METHODS: H...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149189/ https://www.ncbi.nlm.nih.gov/pubmed/37088035 http://dx.doi.org/10.1016/j.ebiom.2023.104565 |