Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib

Upon activation by RAS, RAF family kinases initiate signaling through the MAP kinase cascade to control cell growth, proliferation, and differentiation. Among RAF isoforms (ARAF, BRAF, and CRAF), oncogenic mutations are by far most frequent in BRAF. The BRAF(V600E) mutation drives more than half of...

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Detalles Bibliográficos
Autores principales: Tkacik, Emre, Li, Kunhua, Gonzalez-Del Pino, Gonzalo, Ha, Byung Hak, Vinals, Javier, Park, Eunyoung, Beyett, Tyler S., Eck, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149214/
https://www.ncbi.nlm.nih.gov/pubmed/36963492
http://dx.doi.org/10.1016/j.jbc.2023.104634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149214/
https://www.ncbi.nlm.nih.gov/pubmed/36963492
http://dx.doi.org/10.1016/j.jbc.2023.104634

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