MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling

Oxidative stress is considered a key factor contributing to the initiation and development of cardiac injury following ischaemia‒reperfusion (I/R). Arachidonate 5-lipoxygenase (ALOX5) is a rate-limiting enzyme for leukotriene biosynthesis. MK-886 is an inhibitor of ALOX5 that exhibits anti-inflammat...

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Detalles Bibliográficos
Autores principales: Shi, Kai-Na, Li, Pang-Bo, Su, Hui-Xiang, Gao, Jing, Li, Hui-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149391/
https://www.ncbi.nlm.nih.gov/pubmed/37098317
http://dx.doi.org/10.1016/j.redox.2023.102706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149391/
https://www.ncbi.nlm.nih.gov/pubmed/37098317
http://dx.doi.org/10.1016/j.redox.2023.102706

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