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MK-886 protects against cardiac ischaemia/reperfusion injury by activating proteasome-Keap1-NRF2 signalling

Oxidative stress is considered a key factor contributing to the initiation and development of cardiac injury following ischaemia‒reperfusion (I/R). Arachidonate 5-lipoxygenase (ALOX5) is a rate-limiting enzyme for leukotriene biosynthesis. MK-886 is an inhibitor of ALOX5 that exhibits anti-inflammat...

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Detalles Bibliográficos
Autores principales:	Shi, Kai-Na, Li, Pang-Bo, Su, Hui-Xiang, Gao, Jing, Li, Hui-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149391/ https://www.ncbi.nlm.nih.gov/pubmed/37098317 http://dx.doi.org/10.1016/j.redox.2023.102706

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