The impact of pathogenic and artificial mutations on Claudin-5 selectivity from molecular dynamics simulations

Tight-junctions (TJs) are multi-protein complexes between adjacent endothelial or epithelial cells. In the blood-brain-barrier (BBB), they seal the paracellular space and the Claudin-5 (Cldn5) protein forms their backbone. Despite the fundamental role in brain homeostasis, little is known on Cldn5-b...

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Detalles Bibliográficos
Autores principales: Berselli, Alessandro, Alberini, Giulio, Benfenati, Fabio, Maragliano, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149405/
https://www.ncbi.nlm.nih.gov/pubmed/37138900
http://dx.doi.org/10.1016/j.csbj.2023.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149405/
https://www.ncbi.nlm.nih.gov/pubmed/37138900
http://dx.doi.org/10.1016/j.csbj.2023.04.001

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