Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum

Among the genes involved in the biosynthesis of trichothecene (Tri genes), Tri6 and Tri10 encode a transcription factor with unique Cys(2)His(2) zinc finger domains and a regulatory protein with no consensus DNA-binding sequences, respectively. Although various chemical factors, such as nitrogen nut...

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Autores principales: Liew, Maydelene Xiao Xuan, Nakajima, Yuichi, Maeda, Kazuyuki, Kitamura, Naotsugu, Kimura, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149712/
https://www.ncbi.nlm.nih.gov/pubmed/37138602
http://dx.doi.org/10.3389/fmicb.2023.1148771
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author Liew, Maydelene Xiao Xuan
Nakajima, Yuichi
Maeda, Kazuyuki
Kitamura, Naotsugu
Kimura, Makoto
author_facet Liew, Maydelene Xiao Xuan
Nakajima, Yuichi
Maeda, Kazuyuki
Kitamura, Naotsugu
Kimura, Makoto
author_sort Liew, Maydelene Xiao Xuan
collection PubMed
description Among the genes involved in the biosynthesis of trichothecene (Tri genes), Tri6 and Tri10 encode a transcription factor with unique Cys(2)His(2) zinc finger domains and a regulatory protein with no consensus DNA-binding sequences, respectively. Although various chemical factors, such as nitrogen nutrients, medium pH, and certain oligosaccharides, are known to influence trichothecene biosynthesis in Fusarium graminearum, the transcriptional regulatory mechanism of Tri6 and Tri10 genes is poorly understood. Particularly, culture medium pH is a major regulator in trichothecene biosynthesis in F. graminearum, but it is susceptible to metabolic changes posed by nutritional and genetic factors. Hence, appropriate precautions should be considered to minimize the indirect influence of pH on the secondary metabolism while studying the roles of nutritional and genetic factors on trichothecene biosynthesis regulation. Additionally, it is noteworthy that the structural changes of the trichothecene gene cluster core region exert considerable influence over the normal regulation of Tri gene expression. In this perspective paper, we consider a revision of our current understanding of the regulatory mechanism of trichothecene biosynthesis in F. graminearum and share our idea toward establishing a regulatory model of Tri6 and Tri10 transcription.
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spelling pubmed-101497122023-05-02 Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum Liew, Maydelene Xiao Xuan Nakajima, Yuichi Maeda, Kazuyuki Kitamura, Naotsugu Kimura, Makoto Front Microbiol Microbiology Among the genes involved in the biosynthesis of trichothecene (Tri genes), Tri6 and Tri10 encode a transcription factor with unique Cys(2)His(2) zinc finger domains and a regulatory protein with no consensus DNA-binding sequences, respectively. Although various chemical factors, such as nitrogen nutrients, medium pH, and certain oligosaccharides, are known to influence trichothecene biosynthesis in Fusarium graminearum, the transcriptional regulatory mechanism of Tri6 and Tri10 genes is poorly understood. Particularly, culture medium pH is a major regulator in trichothecene biosynthesis in F. graminearum, but it is susceptible to metabolic changes posed by nutritional and genetic factors. Hence, appropriate precautions should be considered to minimize the indirect influence of pH on the secondary metabolism while studying the roles of nutritional and genetic factors on trichothecene biosynthesis regulation. Additionally, it is noteworthy that the structural changes of the trichothecene gene cluster core region exert considerable influence over the normal regulation of Tri gene expression. In this perspective paper, we consider a revision of our current understanding of the regulatory mechanism of trichothecene biosynthesis in F. graminearum and share our idea toward establishing a regulatory model of Tri6 and Tri10 transcription. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10149712/ /pubmed/37138602 http://dx.doi.org/10.3389/fmicb.2023.1148771 Text en Copyright © 2023 Liew, Nakajima, Maeda, Kitamura and Kimura. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Liew, Maydelene Xiao Xuan
Nakajima, Yuichi
Maeda, Kazuyuki
Kitamura, Naotsugu
Kimura, Makoto
Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum
title Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum
title_full Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum
title_fullStr Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum
title_full_unstemmed Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum
title_short Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum
title_sort regulatory mechanism of trichothecene biosynthesis in fusarium graminearum
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149712/
https://www.ncbi.nlm.nih.gov/pubmed/37138602
http://dx.doi.org/10.3389/fmicb.2023.1148771
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