Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction

BACKGROUND: Phosphorylation of diacylglycerol by diacylglycerol-kinases represents a major inhibitory event constraining T cell activation upon antigen engagement. Efficient TCR signalling requires the inhibition of the alpha isoform of diacylglycerol kinase, DGKα, by an unidentified signalling path...

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Detalles Bibliográficos
Autores principales: Velnati, Suresh, Centonze, Sara, Rossino, Giulia, Purghè, Beatrice, Antona, Annamaria, Racca, Luisa, Mula, Sabrina, Ruffo, Elisa, Malacarne, Valeria, Malerba, Mario, Manfredi, Marcello, Graziani, Andrea, Baldanzi, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149931/
https://www.ncbi.nlm.nih.gov/pubmed/37138877
http://dx.doi.org/10.3389/fimmu.2023.1043603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149931/
https://www.ncbi.nlm.nih.gov/pubmed/37138877
http://dx.doi.org/10.3389/fimmu.2023.1043603

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