FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease

Cardiac ryanodine receptors (RyR2) release the Ca(2+) from intracellular stores that is essential for cardiac myocyte contraction. The ion channel opening is tightly regulated by intracellular factors, including the FK506 binding proteins, FKBP12 and FKBP12.6. The impact of these proteins on RyR2 ac...

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Detalles Bibliográficos
Autores principales: Richardson, S. J., Thekkedam, C. G., Casarotto, M. G., Beard, N. A., Dulhunty, A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Part III: Ca2+ Homeostasis and Excitation Contraction Coupling
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150220/
https://www.ncbi.nlm.nih.gov/pubmed/37122219
http://dx.doi.org/10.1098/rstb.2022.0169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150220/
https://www.ncbi.nlm.nih.gov/pubmed/37122219
http://dx.doi.org/10.1098/rstb.2022.0169

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