Oral IRAK-4 Inhibitor CA-4948 Is Blood-Brain Barrier Penetrant and Has Single-Agent Activity against CNS Lymphoma and Melanoma Brain Metastases

PURPOSE: An ongoing challenge in cancer is the management of primary and metastatic brain malignancies. This is partly due to restrictions of the blood-brain barrier and their unique microenvironment. These challenges are most evident in cancers such as lymphoma and melanoma, which are typically res...

Descripción completa

Detalles Bibliográficos
Autores principales: Von Roemeling, Christina A., Doonan, Bently P., Klippel, Kelena, Schultz, Daniel, Hoang-Minh, Lan, Trivedi, Vrunda, Li, Chenglong, Russell, Rylynn A., Kanumuri, Raju S., Sharma, Abhisheak, Tun, Han W., Mitchell, Duane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150246/
https://www.ncbi.nlm.nih.gov/pubmed/36749885
http://dx.doi.org/10.1158/1078-0432.CCR-22-1682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150246/
https://www.ncbi.nlm.nih.gov/pubmed/36749885
http://dx.doi.org/10.1158/1078-0432.CCR-22-1682

Ejemplares similares