Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer

[Image: see text] CDC42 GTPases (RHOJ, CDC42, and RHOQ) are overexpressed in multiple tumor types and activate pathways critical for tumor growth, angiogenesis, and metastasis. Recently, we reported the discovery of a novel lead compound, ARN22089, which blocks the interaction of CDC42 GTPases with...

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Detalles Bibliográficos
Autores principales: Brindani, Nicoletta, Vuong, Linh M., Acquistapace, Isabella Maria, La Serra, Maria Antonietta, Ortega, José Antonio, Veronesi, Marina, Bertozzi, Sine Mandrup, Summa, Maria, Girotto, Stefania, Bertorelli, Rosalia, Armirotti, Andrea, Ganesan, Anand K., De Vivo, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150367/
https://www.ncbi.nlm.nih.gov/pubmed/37026468
http://dx.doi.org/10.1021/acs.jmedchem.3c00276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150367/
https://www.ncbi.nlm.nih.gov/pubmed/37026468
http://dx.doi.org/10.1021/acs.jmedchem.3c00276

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