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Expression of Myomaker and Myomerger in myofibers causes muscle pathology

BACKGROUND: Skeletal muscle development and regeneration depend on cellular fusion of myogenic progenitors to generate multinucleated myofibers. These progenitors utilize two muscle-specific fusogens, Myomaker and Myomerger, which function by remodeling cell membranes to fuse to each other or to exi...

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Detalles Bibliográficos
Autores principales: Witcher, Phillip C., Sun, Chengyi, Millay, Douglas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150476/
https://www.ncbi.nlm.nih.gov/pubmed/37127758
http://dx.doi.org/10.1186/s13395-023-00317-z