Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells

BACKGROUND: SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these cells inactivating the enzymatic activity. To...

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Detalles Bibliográficos
Autores principales: Tsai, Ming-Han C., Caswell, Sarah J., Morris, Elizabeth R., Mann, Melanie C., Pennell, Simon, Kelly, Geoff, Groom, Harriet C. T., Taylor, Ian A., Bishop, Kate N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150492/
https://www.ncbi.nlm.nih.gov/pubmed/37127613
http://dx.doi.org/10.1186/s12977-023-00620-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150492/
https://www.ncbi.nlm.nih.gov/pubmed/37127613
http://dx.doi.org/10.1186/s12977-023-00620-z

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