Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells

BACKGROUND: SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these cells inactivating the enzymatic activity. To...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsai, Ming-Han C., Caswell, Sarah J., Morris, Elizabeth R., Mann, Melanie C., Pennell, Simon, Kelly, Geoff, Groom, Harriet C. T., Taylor, Ian A., Bishop, Kate N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150492/
https://www.ncbi.nlm.nih.gov/pubmed/37127613
http://dx.doi.org/10.1186/s12977-023-00620-z

Ejemplares similares

Ejemplares similares