Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition

BACKGROUND: Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be classified into four major subgroups based on gene expression and genomic features. Single-cell transcriptome studies have defined the cellular states underlying each MB subgroup; however, the spatial organisation...

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Detalles Bibliográficos
Autores principales: Vo, Tuan, Balderson, Brad, Jones, Kahli, Ni, Guiyan, Crawford, Joanna, Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Kojic, Marija, Robertson, Thomas, Walters, Shaun, Mulay, Onkar, Bhuva, Dharmesh D., Davis, Melissa J., Wainwright, Brandon J., Nguyen, Quan, Genovesi, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150495/
https://www.ncbi.nlm.nih.gov/pubmed/37127652
http://dx.doi.org/10.1186/s13073-023-01185-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150495/
https://www.ncbi.nlm.nih.gov/pubmed/37127652
http://dx.doi.org/10.1186/s13073-023-01185-4

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