Boosting genome editing efficiency in human cells and plants with novel LbCas12a variants

BACKGROUND: Cas12a (formerly known as Cpf1), the class II type V CRISPR nuclease, has been widely used for genome editing in mammalian cells and plants due to its distinct characteristics from Cas9. Despite being one of the most robust Cas12a nucleases, LbCas12a in general is less efficient than SpC...

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Detalles Bibliográficos
Autores principales: Zhang, Liyang, Li, Gen, Zhang, Yingxiao, Cheng, Yanhao, Roberts, Nathaniel, Glenn, Steve E., DeZwaan-McCabe, Diane, Rube, H. Tomas, Manthey, Jeff, Coleman, Gary, Vakulskas, Christopher A., Qi, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150537/
https://www.ncbi.nlm.nih.gov/pubmed/37122009
http://dx.doi.org/10.1186/s13059-023-02929-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150537/
https://www.ncbi.nlm.nih.gov/pubmed/37122009
http://dx.doi.org/10.1186/s13059-023-02929-6

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