Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFR(L858R/T790M) inhibitors

EGFR mutations have been identified in 20,000 reported NSCLC (non-small cell lung cancer) samples, and exon 19 deletions and L858R mutations at position 21, known as “classical” mutations, account for 85–90% of the total EGFR (epidermal growth factor receptor) mutations. In this paper, two series of...

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Detalles Bibliográficos
Autores principales: Fu, Jianfang, Yu, Jie, Zhang, Xiang, Chang, Yaoyao, Fan, Hongze, Dong, Mengzhen, Li, Mengjia, Liu, Yue, Hu, Jinxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150624/
https://www.ncbi.nlm.nih.gov/pubmed/37106478
http://dx.doi.org/10.1080/14756366.2023.2205605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150624/
https://www.ncbi.nlm.nih.gov/pubmed/37106478
http://dx.doi.org/10.1080/14756366.2023.2205605

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