The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress

Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an antifungal drug can contribute to therapeutic f...

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Detalles Bibliográficos
Autores principales: Yau, Ka Pui Sharon, Weerasinghe, Harshini, Olivier, Francios A. B., Lo, Tricia L., Powell, David R., Koch, Barbara, Beilharz, Traude H., Traven, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150987/
https://www.ncbi.nlm.nih.gov/pubmed/37075064
http://dx.doi.org/10.1371/journal.ppat.1011338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150987/
https://www.ncbi.nlm.nih.gov/pubmed/37075064
http://dx.doi.org/10.1371/journal.ppat.1011338

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