Tight junction protein occludin is an internalization factor for SARS-CoV-2 infection and mediates virus cell-to-cell transmission

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads efficiently by spike-mediated, direct cell-to-cell transmission. However, the underlying mechanism is poorly understood. Herein, we demonstrate that the tight junction protein occludin (OCLN) is critical to this process. SARS-CoV-2...

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Detalles Bibliográficos
Autores principales: Zhang, Jialin, Yang, Wenyu, Roy, Sawrab, Liu, Heidi, Roberts, R. Michael, Wang, Liping, Shi, Lei, Ma, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151465/
https://www.ncbi.nlm.nih.gov/pubmed/37068248
http://dx.doi.org/10.1073/pnas.2218623120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151465/
https://www.ncbi.nlm.nih.gov/pubmed/37068248
http://dx.doi.org/10.1073/pnas.2218623120

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