Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies

The hemagglutinin (HA) stem region is a major target of universal influenza vaccine efforts owing to the presence of highly conserved epitopes across multiple influenza A virus (IAV) strains and subtypes. To explore the potential impact of vaccine-induced immunity targeting the HA stem, we examined...

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Detalles Bibliográficos
Autores principales: Lee, Chung-Young, Raghunathan, Vedhika, Caceres, C. Joaquin, Geiger, Ginger, Seibert, Brittany, Cargnin Faccin, Flavio, Gay, L. Claire, Ferreri, Lucas M., Kaul, Drishti, Wrammert, Jens, Tan, Gene S., Perez, Daniel R., Lowen, Anice C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151473/
https://www.ncbi.nlm.nih.gov/pubmed/37068231
http://dx.doi.org/10.1073/pnas.2208718120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151473/
https://www.ncbi.nlm.nih.gov/pubmed/37068231
http://dx.doi.org/10.1073/pnas.2208718120

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