Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies

Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside analogues have been widely used as anticancer drugs for the treatment of a variety of conditions, including gastrointestinal malignancies. However, low permeability, enzymatic deamination, inefficiently phosphoryla...

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Autores principales: Xu, Xingxing, Li, Zixuan, Yao, Xueying, Sun, Nannan, Chang, Junbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151537/
https://www.ncbi.nlm.nih.gov/pubmed/37143892
http://dx.doi.org/10.3389/fcell.2023.1173432
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author Xu, Xingxing
Li, Zixuan
Yao, Xueying
Sun, Nannan
Chang, Junbiao
author_facet Xu, Xingxing
Li, Zixuan
Yao, Xueying
Sun, Nannan
Chang, Junbiao
author_sort Xu, Xingxing
collection PubMed
description Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside analogues have been widely used as anticancer drugs for the treatment of a variety of conditions, including gastrointestinal malignancies. However, low permeability, enzymatic deamination, inefficiently phosphorylation, the emergence of chemoresistance and some other issues have limited its efficacy. The prodrug strategies have been widely applied in drug design to improve pharmacokinetic properties and address safety and drug-resistance issues. This review will provide an overview of the recent developments of prodrug strategies in nucleoside analogues for the treatment of gastrointestinal malignancies.
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spelling pubmed-101515372023-05-03 Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies Xu, Xingxing Li, Zixuan Yao, Xueying Sun, Nannan Chang, Junbiao Front Cell Dev Biol Cell and Developmental Biology Gastrointestinal malignancies are common digestive system tumor worldwide. Nucleoside analogues have been widely used as anticancer drugs for the treatment of a variety of conditions, including gastrointestinal malignancies. However, low permeability, enzymatic deamination, inefficiently phosphorylation, the emergence of chemoresistance and some other issues have limited its efficacy. The prodrug strategies have been widely applied in drug design to improve pharmacokinetic properties and address safety and drug-resistance issues. This review will provide an overview of the recent developments of prodrug strategies in nucleoside analogues for the treatment of gastrointestinal malignancies. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151537/ /pubmed/37143892 http://dx.doi.org/10.3389/fcell.2023.1173432 Text en Copyright © 2023 Xu, Li, Yao, Sun and Chang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Xu, Xingxing
Li, Zixuan
Yao, Xueying
Sun, Nannan
Chang, Junbiao
Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
title Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
title_full Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
title_fullStr Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
title_full_unstemmed Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
title_short Advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
title_sort advanced prodrug strategies in nucleoside analogues targeting the treatment of gastrointestinal malignancies
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151537/
https://www.ncbi.nlm.nih.gov/pubmed/37143892
http://dx.doi.org/10.3389/fcell.2023.1173432
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AT sunnannan advancedprodrugstrategiesinnucleosideanaloguestargetingthetreatmentofgastrointestinalmalignancies
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