Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects

Amplification of HER2 can drive the proliferation of cancer cells, and several inhibitors of HER2 have been successfully developed. Recent advances in next-generation sequencing now reveal that HER2 is subject to mutation, with over 2,000 unique variants observed in human cancers. Several examples o...

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Detalles Bibliográficos
Autores principales: Ishiyama, Noboru, O'Connor, Matthew, Salomatov, Andrei, Romashko, Darlene, Thakur, Shalabh, Mentes, Ahmet, Hopkins, Julia F., Frampton, Garrett M., Albacker, Lee A., Kohlmann, Anna, Roberts, Christopher, Buck, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Computational Cancer Biology and Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152233/
https://www.ncbi.nlm.nih.gov/pubmed/35503682
http://dx.doi.org/10.1158/0008-5472.CAN-21-0940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152233/
https://www.ncbi.nlm.nih.gov/pubmed/35503682
http://dx.doi.org/10.1158/0008-5472.CAN-21-0940

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