Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism

α-Fetoprotein (AFP) is expressed by stem-like and poor outcome hepatocellular cancer tumors and is a clinical tumor biomarker. AFP has been demonstrated to inhibit dendritic cell (DC) differentiation and maturation and to block oxidative phosphorylation. To identify the critical metabolic pathways l...

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Detalles Bibliográficos
Autores principales: Munson, Paul V., Adamik, Juraj, Hartmann, Felix J., Favaro, Patricia M.B., Ho, Daniel, Bendall, Sean C., Combes, Alexis J., Krummel, Matthew F., Zhang, Karen, Kelley, Robin K., Butterfield, Lisa H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Convergence Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152238/
https://www.ncbi.nlm.nih.gov/pubmed/36847613
http://dx.doi.org/10.1158/0008-5472.CAN-22-3551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152238/
https://www.ncbi.nlm.nih.gov/pubmed/36847613
http://dx.doi.org/10.1158/0008-5472.CAN-22-3551

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