Applying Na/Co(ii) bimetallic partnerships to promote multiple Co–H exchanges in polyfluoroarenes

Heterobimetallic base NaCo(HMDS)(3) [HMDS = N(SiMe(3))(2)] enables regioselective di-cobaltation of activated polyfluoroarenes under mild reaction conditions. For 1,3,5-C(6)H(2)X(3) (X= Cl, F), NaCo(HMDS)(3) in excess at 80 °C impressively induces the collective cleavage of five bonds (two C–H and t...

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Detalles Bibliográficos
Autores principales: Logallo, Alessandra, Hevia, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152514/
https://www.ncbi.nlm.nih.gov/pubmed/37060131
http://dx.doi.org/10.1039/d3cc01216f
Descripción
Sumario:Heterobimetallic base NaCo(HMDS)(3) [HMDS = N(SiMe(3))(2)] enables regioselective di-cobaltation of activated polyfluoroarenes under mild reaction conditions. For 1,3,5-C(6)H(2)X(3) (X= Cl, F), NaCo(HMDS)(3) in excess at 80 °C impressively induces the collective cleavage of five bonds (two C–H and three C–X) of the substrates via a cascade activation process that cannot be replicated by LiCo(HMDS)(3) or KCo(HMDS)(3).

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