Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new t...

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Autores principales: Sharifi-Rad, Javad, Seidel, Veronique, Izabela, Michalak, Monserrat-Mequida, Margalida, Sureda, Antoni, Ormazabal, Valeska, Zuniga, Felipe A., Mangalpady, Shivaprasad Shetty, Pezzani, Raffaele, Ydyrys, Alibek, Tussupbekova, Gulmira, Martorell, Miquel, Calina, Daniela, Cho, William C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152593/
https://www.ncbi.nlm.nih.gov/pubmed/37127651
http://dx.doi.org/10.1186/s12964-023-01109-0
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author Sharifi-Rad, Javad
Seidel, Veronique
Izabela, Michalak
Monserrat-Mequida, Margalida
Sureda, Antoni
Ormazabal, Valeska
Zuniga, Felipe A.
Mangalpady, Shivaprasad Shetty
Pezzani, Raffaele
Ydyrys, Alibek
Tussupbekova, Gulmira
Martorell, Miquel
Calina, Daniela
Cho, William C.
author_facet Sharifi-Rad, Javad
Seidel, Veronique
Izabela, Michalak
Monserrat-Mequida, Margalida
Sureda, Antoni
Ormazabal, Valeska
Zuniga, Felipe A.
Mangalpady, Shivaprasad Shetty
Pezzani, Raffaele
Ydyrys, Alibek
Tussupbekova, Gulmira
Martorell, Miquel
Calina, Daniela
Cho, William C.
author_sort Sharifi-Rad, Javad
collection PubMed
description Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01109-0.
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spelling pubmed-101525932023-05-03 Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy Sharifi-Rad, Javad Seidel, Veronique Izabela, Michalak Monserrat-Mequida, Margalida Sureda, Antoni Ormazabal, Valeska Zuniga, Felipe A. Mangalpady, Shivaprasad Shetty Pezzani, Raffaele Ydyrys, Alibek Tussupbekova, Gulmira Martorell, Miquel Calina, Daniela Cho, William C. Cell Commun Signal Review Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01109-0. BioMed Central 2023-05-01 /pmc/articles/PMC10152593/ /pubmed/37127651 http://dx.doi.org/10.1186/s12964-023-01109-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sharifi-Rad, Javad
Seidel, Veronique
Izabela, Michalak
Monserrat-Mequida, Margalida
Sureda, Antoni
Ormazabal, Valeska
Zuniga, Felipe A.
Mangalpady, Shivaprasad Shetty
Pezzani, Raffaele
Ydyrys, Alibek
Tussupbekova, Gulmira
Martorell, Miquel
Calina, Daniela
Cho, William C.
Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
title Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
title_full Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
title_fullStr Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
title_full_unstemmed Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
title_short Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
title_sort phenolic compounds as nrf2 inhibitors: potential applications in cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152593/
https://www.ncbi.nlm.nih.gov/pubmed/37127651
http://dx.doi.org/10.1186/s12964-023-01109-0
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